Myocardial hypertrophy and heart failure

Model of ischemic heart failure

Rats, pigs, dogs, NHPs

1) Ultrasonic cardiogram

2) Invasive hemodynamic monitoring

3) Electrocardiogram

4) Myocardial enzymogram and biochemical examination

Histopathology

Drug-induced model of heart failure

Rats

Tachypacing-induced heart failure model

Dogs

Volume overload-induced model for heart failure

Pigs, dogs, NHPs, etc.

Myocardial ischemia and myocardial infarction

LAD ligation model

Mice, rats, pigs,   dogs, NHPs

1) Ultrasonic cardiogram

2) Invasive hemodynamic monitoring

3) Electrocardiogram

4) Myocardial enzymogram and biochemical examination

Histopathology

Coronary occlusion model

Pigs, dogs, NHPs

ISO-induced model

Rats

1) Behavioral neurological scorin

2) TTC staining

3) Grip test

4) Novel object recognition

5) Cerebral blood flow

Pulmonary arterial hypertension (PAH)

Monocrotaline (MCT) induced PAH model

Rats

1) Right ventricular systolic pressure (RVSP)

2) Right ventricular hypertrophy index (RVHI)

3) Histopathology

Hypertension

1) Blood Biochemistry and Routine Blood Tests

2) Blood pressure monitoring

3) Electrocardiogram (ECG)

Genetic models

SHR / DSS rats

2-kidney-1-clip   model

rats

1) Platelet aggregation inhibition rat

2) Thrombus weight

3) Bleeding time

4) Coagulation function

5) Skin blood flow

1) Coagulation function (FBG, TT, etc.

2) Histopathological quantification of pulmonary thrombi

3) Angiography (dogs/NHPs)

4) Hemodynamics

5) Plasma biomarkers

1) Limb morphology scorin

2) Bblood flow measurement in the affected limb

1) Bederson scor

2) Garcia JH score

3) Histopathology

Cardiac arrhythmia

Epinephrine-induced arrhythmia model

Rats, rabbits

1) Ultrasonic cardiogram

2) Electrocardiogram