Animal models of Cardiovascular Diseases - Greentech Bioscience Preclinical CRO Services

Greentech Bioscience boasts years of experience in pharmacology and pharmacodynamics, especially in the field of cardiovascular diseases. We have established a number of validated animal models of cardiovascular diseases, ensuring high quality, reproducible data. In addition to our established models, we can also develop novel models according to your requirements.

Our Animal Models of Cardio-Cerebrovascular Diseases

Diseases	Animal Models	Species	Clinical Assessment
Myocardial hypertrophy and heart failure	Models of ischemic heart failure	Rats, pigs, dogs, NHPs	· Ultrasonic cardiogram · Invasive hemodynamic monitoring · Electrocardiogram · Myocardial enzymogram and biochemical examination · Histopathology
	Transverse aortic constriction (TAC) model	Mice, rats
	Drug-induced heart failure models	Rats
	Rapid pacing-induced heart failure models	Dogs
Myocardial ischemia and myocardial infarction	LAD ligation models	Mice, rats, pigs, dogs, NHPs	· Ultrasonic cardiogram · Invasive hemodynamic monitoring · Electrocardiogram · Myocardial enzymogram and biochemical examination · Histopathology
	Coronary occlusion models	Pigs, dogs, NHPs
	ISO-induced model	Rats
Pulmonary arterial hypertension (PAH)	Monocrotaline (MCT) induced PAH model	Rats	· Right ventricular systolic pressure (RVSP) · Right ventricular hypertrophy index (RVHI) · Histopathology
Hypertension	Genetic models	SHR / DSS rats	· Blood Biochemistry and Routine Blood Tests · Blood pressure monitoring · Electrocardiogram (ECG)
Hypertension	2-kidney-1-clip model	rats
Cardiac arrhythmia	Epinephrine-induced arrhythmia model	Rats, rabbits	· Ultrasonic cardiogram · Electrocardiogram