Pain & Analgesia
Pain is a highly important health problem. Current’s therapies for pain is limited by both adverse side effects and lack of efficacy. Pain is not a unitary phenomenon, involving multiple etiologies and different pathophysiologies. Greentech Bioscience offers a number of animal models of pain to better understand pain from a variety of disease states and develop effective therapies.
Our Animal Models of Pain
Diseases | Animal Models | Species | Clinical Assessment |
Rat plantar incision model | Rats | (1) Mechanical hyperalgesia (2) Hot/cold plate | |
Porcine incisional pain model | Pigs | Mechanical hyperalgesia | |
Formalin-induced inflammatory pain model | Mice, rats | (1) Spontaneous pain (2) Behavioral tests: mechanical hyperalgesia, thermal hyperalgesia, incapacitance test | |
Capsaicin-induced inflammatory pain model | |||
CFA-induced inflammatory pain model | |||
MIA induced osteoarthritis pain model | Mice, rats, rabbits | (1) Behavioral tests: mechanical hyperalgesia, thermal hyperalgesia, gait analysis, incapacitance test (2) Optional indexes: histopathology, micro-CT | |
MMT | |||
ACLT | |||
Paclitaxel-induced neuropathic pain model | Rats | (1) Abnormal behaviors (2) Behavioral tests: mechanical threshold and thermal threshold (3) 5-HT and NO levels | |
STZ induced diabetic neuropathic pain model | Mice, rats | ||
Peripheral nerve injury: CCI, PSL, SNI | Rats | ||
NTG-induced migraine | Mice, rats | (1) Survival, food/water intake (2) Oral mucosal injury score (3) Histopathology | |
Capsaicin induced dermal blood flow | Rats, NHPs | Skin blood flow (DBF) | |
Tumor inoculation into bone marrow cavity | Mice | Behavioral tests: mechanical threshold, paw withdrawal threshold, incapacitance test | |
Acetic acid induced writhing | Mice, rats | Writhing frequency |
Pain Assessment Platform
Greentech Bioscience developed a comprehensive pain assessment platform which includes multiple motor and sensory evaluation devices such as Von Frey filaments, Tail-Flick test, incapacitance test, Hargreaves test, gait analysis, RotaRod test, treadmills, hot/cold plate, TopScan behavior tracking, etc.
Figure 1. The pain assessment platform at Greentech Bioscience.
Inquiries
Request a quote now, or email us at BD@greentech-bio.com to inquire about our services or obtain a quote for your project.
Reference
Mogil JS.Animal models of pain: progress and challenges.[J].Nat Rev Neurosci,2009,4:283-94.
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