Metabolic Diseases

NAFLD/NASH Liver Injury, Cirrhosis, Failure Renal Failure Diabetes and Its Complications Hyperuricemia and Gout

Cardio-cerebrovascular Diseases

Psychiatry & Neurology

Oncology

Metabolic Diseases

Inflammation & Autoimmune Diseases

Pain & Analgesia

Bone, Joint & Cartilage Diseases

DMPK & Non-GLP Toxicology

In Vitro Drug Screening

In Vitro Drug Screening

Efficacy Testing for Medical Devices

Greentech Bioscience boasts years of experience in pharmacology and pharmacodynamics. We have accumulated extensive experience in the field of metabolic diseases and established a number of validated animal models, delivering high quality, reproducible data. In addition to our established models, we can also develop novel models according to your requirements.

Our Animal Models for Metabolic Diseases

Diseases	Animal Models	Species	Clinical Assessment
NAFLD/NASH	MCD/CDAA model	Mice	(1) Body weight, liver index, food intake (2) ALT, AST, ALP (3) TC, HDL, LDL, TG, T-BIL (4) GLU, INS, HOMA-IR (5) HE, MASSON, Oil Red O, Sirius Red staining (6) Detection of collagen and hydroxyproline
	HFD model	Mice, rats
	HFD+CCl₄ model	Rats
	HFD+STZ model	Rats
	CCl₄ model	Mice, rats
	STAM model	Neonatal mice
	Western diet model	Mice, rats
Acute liver injury & cirrhosis	CCL₄/Alcohol/Acetaminophen induced acute liver injury	Mice, rats, pigs, dogs, NHPs	(1) Body weight, liver index, food intake (2) ALT, AST, ALB, LDH, etc. (3) TC, HDL, LDL, TG, etc. (4) T-BIL, D-BIL, I-BIL (5) ALP, GGT (6) HE, Masson staining (7) Hepatic fibrosis: detection of collagen and hydroxyproline (8) Imaging: color ultrasound, CT, PET/CT, etc.
	D-gal/BDL induced acute liver failure model	Mice, rats, dogs
	ANIT/BDL/2-OA+BSA induced primary biliary cirrhosis (PBC) model	Mice, rats
	DDC induced primary sclerosing cholangitis (PSC) model	Mice
Renal failure	5/6 nephrectomy model	Mice, rats	(1) Serum/urine biochemistry (2) Serum immunoassay (3) Histopathology: HE/PAS/Masson staining (4) IHC, RT-qPCR
Renal failure	Partial ligation of the abdominal aorta	Mice, rats
Hypertension	Genetic models	SHR / DSS rats	(1) Blood biochemistry and routine blood tests (2) Blood pressure monitoring (3) Electrocardiogram (ECG)
Hypertension	2-kidney-1-clip model	Rats
Diabetes and its complications	STZ induced type I diabetes	Mice, rats	(1) Blood glucose, HbA1C, insulin level (2) Blood biochemistry (3) OGTT, IVGTT, ITT
	Spontaneous type II diabetic rodent model	ob/ob mice, db/db mice, ZDF rats
	Diabetic foot ulcer model	Mice, rats	(1) Wound measurement and healing rate (2) Histopathology, IHC
	Models of diabetic nephropathy	Mice, rats	(1) Blood glucose (2) Kidney function (3) Histopathology & IHC
Hyperuricemia	HX/PO induced hyperuricemia	Mice, rats	Serum UA, Cr, BUN
Gout	MSU air pouch model	Mice, rats, rabbits	(1) Caliper measurement (2) Pain assessment (3) Inflammation evaluation (4) Histopathological assessment
Gout	MSU induced gouty arthritis model	Mice, rats, rabbits
Hyperlipidemia	High-fat diet-induced model	Golden hamster	TC, TG, HDL-C, LDL-C
Hyperlipidemia	Transgenic model	Mice	TC, TG, HDL-C, LDL-C

Inquiries

Request a quote now, or email us at BD@greentech-bio.com to inquire about our services or obtain a quote for your project.