Inflammation & Autoimmune Diseases

Inflammation & Autoimmune Diseases

Greentech Bioscience boasts years of experience in pharmacology and pharmacodynamics. We have established a number of validated animal models of inflammation and animal models of autoimmune diseases for preclinical efficacy testing of novel therapies. In addition to our established models, we can also customize novel models to meet specific requirements of customers.

Our Animal Models for Inflammation & Autoimmune Diseases


Animal Models


Clinical Assessment

Rheumatoid Arthritis

Collagen-induced arthritis model


(1) Rheumatoid arthritis score

(2) Paw volume, ankle diameter

(3) ELISA: plasma IL-6, IL-17, TNF-alpha, etc.

(4) Joint histopathology

Adjuvant-induced arthritis model


Imiquimod-induced psoriasis model


(1) Psoriasis area severity index (PASI)

(2) Histopathology: H&E staining

(3) Immunostaining: MPO, CD3+, etc.

(4) qPCR: IL-17A, IL-17F, IL-23, TNF-α, IFN-γ, IL-6, IL-17, etc.

Multiple Sclerosis (MS)

Experimental autoimmune encephalomyelitis (EAE) model

SJL/J mice

(1) Body weight

(2) Neurological function score

Systemic Sclerosis (SSc)

Bleomycin-induced SSc model


(1) Histopathology

(2) Immunostaining: TGF-β

(3) Hydroxyproline content

(4) Serum ANA/ENA testing

Oral Mucositis

Radiation-induced   oral mucositis model

Rats, golden hamsters

(1) Survival, food/water intake

(2) Oral mucosal injury score

(3) Histopathology

Idiopathic Pulmonary Fibrosis (IPF)

Bleomycin induced lung fibrosis model

Rats, golden hamsters

(1) Body weight

(2) Inflammatory cell count of BALFs

(3) Measurement of HYP

(4) Histopathology

Silica induced pulmonary fibrosis model

Inflammatory Bowel Disease (IBD)

DSS induced IBD model

Mice, rats

(1) Clinical observations

(2) Disease activity index (DAI) scores

(3) Colon length, organ weight

(4) MPO activity measurement

(5) ELISA: serum TNF-α, IL-6, IL-8, IL-1β

(6) Histopathology

TNBS induced IBD model


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