Cardio-cerebrovascular Disease

Models of Hypertension

Greentech Bioscience is proud to offer high-quality animal models of experimental hypertension for efficient drug efficacy testing, facilitating the clinical transformation of novel drugs.

Our Animal Models of Hypertension

1. Genetic Rat Models of Hypertension

Animals: spontaneously hypertensive rats (SHR), Dahl salt-sensitive (DSS) rats, etc.

Disease characteristics: (i) SHR: The blood pressure (BP) increases at 4 to 6 weeks of age with the systolic BP reaching 180–200 mmHg. SHR may develop cardiac hypertrophy, heart failure, renal dysfunction, etc.; (ii) DSS rats: DSS rats become hypertensive on a normal salt diet and develop severe and fatal hypertension with a high salt diet. These rats may develop cardiac hypertrophy, heart failure, hypertensive nephropathy, etc.

2. Animal Model of Renovascular Hypertension (Two-Kidney-One-Clip, 2K1C)

Two-kidney one-clip (2K1C) model is one of the most frequently used models in the induction of renovascular hypertension in mice or rats.

Induction: place a silver clip on the left renal artery to obtain a 50%~80% reduction in blood flow

Species: mice, rats

Disease characteristics: the BP starts to increase from two weeks after surgery and 2K1C rats develop stable hypertension at 4 to 5 weeks post 2K1C surgery.

Clinical Assessment

Blood biochemistry and routine blood tests
Blood pressure monitoring
Electrocardiogram (ECG)
Cardiac color ultrasound


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1. Oparil, S., & Schmieder, R. E. (2015). New Approaches in the Treatment of Hypertension. Circulation Research, 116(6), 1074–1095.

2. Sztuka, K., & Jasińska-Stroschein, M. (2017). Animal models of pulmonary arterial hypertension: A systematic review and meta-analysis of data from 6126 animals. Pharmacological Research, 125, 201–214.