Bioanalysis

Bioanalytics is an essential tool for determining the concentration of biomarkers, drugs and their metabolites in various biological fluids. Bioanalytical method validation serves as a critical step ensuring that quantitative data demonstrate selectivity, accuracy and stability. Greentech provides high quality bioanalysis services including development and validation of LC-MS/MS methods, method transfer, and quantitative sample analysis in human and animal matrices (plasma, tissues, urine and feces), contributing to preclinical and clinical development of novel drug and generic drug. We can work with a range of drug types, such as small molecule chemical drugs, peptides, oligonucleotides, as well as biomarkers.

Our Bioanalysis Services

Bioanalytical method development/validation/transfer

Validation content:

Selectivity

Carry-over

Calibration curve and lower limit of quantification

Accuracy and precision

Dilution integrity

Matrix effect

Stability

Quantitative analysis of biomarkers, drugs and toxins in biological samples

Case Study

Figure 1. Typical validation of selectivity.

Figure 2. Accuracy and precision values of the HPLC-MS/MS method for the determination of a compound in rat plasma.

Figure 3. Chromatograms of plasma blank matrix and LLOQ (5 ng/mL) for AS strand and SS strand in characteristic siRNA determined by LC-MS/MS.

Figure 4. Chromatograms of analytes and corresponding isotope-labeled internal standards for the determination of NE, DA, DOPAC, HVA, and 5-HT concentrations in mouse brain tissue by LC-MS/MS.

Inquiries

Request a quote now, or email us at BD@greentech-bio.com to inquire about our bioanalytical services or obtain a quote for your project.