Model of Traumatic Brain Injury & Spinal Cord Injury  

Neurological injury accounts for around 70% of traffic accident injuries and remains an important factor causing pain, disability and even death. Spinal cord injury (SCI) and traumatic brain injury (TBI) are serious injuries to the nervous system injuries with high disability rate and mortality rate. However, there are currently no effective neuroprotective agents for TBI treatment. In order to further understand the pathophysiology of SCI and TBI and evaluate the neuroprotective effect of drugs, it is necessary to establish suitable animal models that simulate TBI or SCI.

Our Models for TBI / SCI - Controlled Cortical Impact (CCI) Model

Greentech provides controlled cortical impact model to mimic TBI or SCI in humans, which is currently one of the most used models due to high reproducibility.

Induction: spinal cord injury or traumatic brain injury is achieved with a controlled impact device. Subsequently, the skull defect is repaired and the incision is closed.

Advantages: high clinical similarity; high reproducibility; controlled impact strength, depth and duration

Animal Species

Mice, SD rats

Clinical Assessment of TBI Model

(1) Blood pressure

(2) Body temperature

(3) Neurological Severity Scores, NSS

(4) Rotarod test, gait analysis

(5) Histopathology: m-cresol purple staining, pathological diagnosis

Clinical Assessment of SCI Model

(1) Motor behavioral assessments (BBB)

(2) Immunohistochemistry staining

(5) Histopathology: H&E staining, pathological diagnosis

Features

Equipped with neurobehavioral evaluation, histopathology and other supporting facilities

Extensive experience in building animal models of neurological disorders

Experienced neurologic researchers and full-time veterinarians lead the team

Inquiries

Request a quote now, or email us at BD@greentech-bio.com to inquire about our services or obtain a quote for your project.

References

1. Wang Y Q, Wang L, Zhang M Y, et al. Necrostatin-1 suppresses autophagy and apoptosis in mice traumatic brain injury model[J]. Neurochemical research, 2012, 37(9): 1849-1858.

2. Campos-Pires R, Armstrong S P, Sebastiani A, et al. Xenon improves neurological outcome and reduces secondary injury following trauma in an in vivo model of traumatic brain injury[J]. Critical care medicine, 2015, 43(1): 149.

3. Hiruma S, Otsuka K, Satou T, et al. Simple and reproducible model of rat spinal cord injury induced by a controlled cortical impact device[J]. Neurological research, 1999, 21(3): 313-323.