Arrhythmia Models

Cardiac arrhythmias are a major cause of morbidity and mortality worldwide and may arise from inherited genetic disorders or acquired cardiovascular diseases. Reliable preclinical models are essential for investigating disease mechanisms and evaluating the efficacy and safety of novel antiarrhythmic therapies.

Greentech offers a comprehensive portfolio of preclinical arrhythmia models, together with in vivo pharmacology and pharmacodynamic (PD) evaluation services, to support IND-enabling cardiovascular drug development for global pharmaceutical and biotechnology companies.

Our Arrhythmia Models

1. Epinephrine-Induced Arrhythmia Model

Induction: Slow intravenous administration of epinephrine

Animals: Rat, rabbit

2. Left Anterior Descending Coronary Artery (LAD) Ligation-Induced Arrhythmia Model

Induction: Permanent LAD ligation or ischemia/reperfusion (I/R) surgery

Animals: Rat

3. Barium Chloride-Induced Arrhythmia Model

Induction: Intravenous administration of barium chloride solution

Animals: Rat

Clinical Assessment

      1) Echocardiography

      2) Twelve-lead electrocardiography (ECG)

      3) Serum cardiac biomarkers and clinical chemistry analyses

Representative Studies

1. Epinephrine-Induced Rat Arrhythmia Model

Figure 1. Representative ECG recordings during the first 10 minutes following epinephrine administration in the rat arrhythmia model.

2. LAD Ligation-Induced Rat Arrhythmia Model

Figure 2. Arrhythmia analysis in the LAD ligation-induced rat model.

3. Barium Chloride-Induced Rat Arrhythmia Model

Figure 3. Representative ECG recordings during the first 30 minutes following barium chloride administration in the rat arrhythmia model.

References

1. Y.Sarne, I.Hochman, M.Eshed,E Oppenheimer.(1988) Antiarrhythmic action of naloxone: Direct, non-opiate effect on the rat heart. Life Sciences.Volume 43, Issue 10, Pages 859-864.

2. Hamlin, R. L. (2007). Animal models of ventricular arrhythmias. Pharmacology & Therapeutics, 113(2), 276–295.

3. Dobrev, D., & Wehrens, X. H. T. (2018). Mouse Models of Cardiac Arrhythmias. Circulation Research, 123(3), 332–334.

Inquiries

Request a quote now, or email us at BD@greentech-bio.com to inquire about our services or obtain a quote for your project.