Models of Psoriasis

Psoriasis is a chronic, inflammatory skin disorder characterized by epidermal hyperplasia, leukocyte infiltration and increased vascularity in dermis. Greentech Bioscience offers imiquimod (IMQ) induced psoriasis mouse model and the preclinical pharmacological studies are conducted in compliance with GLP requirements.

Imiquimod-Induced Psoriasis Mouse Model

The IMQ-induced psoriatic mouse model is one of the mostly widely used psoriasis-like animal models that mimic various features of the complex cutaneous pathology. IMQ-induced psoriasis in mouse is a rapid, convenient, reproducible model enabling the elucidation of molecular mechanisms and the evaluation of novel therapies against psoriasis. In the model, the mice are shaved on their back and treated with 5% IMQ cream on the back of each mouse. The IMQ-induced psoriasis mouse model exhibits psoriasis-like symptoms after around 5-7 days, including erythema, epidermis thickening and desquamation, and shows similar histological features of psoriasis.

Model Characteristics: IMQ-induced dermatitis in mice exhibits skin lesions, epidermal thickening, keratinization, neovascularization, inflammatory infiltration of T cell subsets, and increased expression of IL-17A, IL-17F and IL-23 genes in the epidermis.

Animal Species: mice

Clinical Assessment

(1) Psoriasis area severity index (PASI)

(2) Histopathology: H&E staining

(3) Immunostaining: MPO, CD3+, etc.

(4) qPCR: IL-17A, IL-17F, IL-23, TNF-α, IFN-γ, IL-6, IL-17, etc.

Case Study

IMQ-induced psoriasis-like mouse model

Inquiries

Request a quote now, or email us at BD@greentech-bio.com to inquire about our services or obtain a quote for your project.

Reference

Jabeen M, et al. Advanced Characterization of Imiquimod-Induced Psoriasis-Like Mouse Model. Pharmaceutics. 2020 Aug 20;12(9):789. doi: 10.3390/pharmaceutics12090789.