Myocardial hypertrophy and heart failure

Models of ischemic heart failure

Rats, pigs, dogs, NHPs

· Ultrasonic cardiogram

· Invasive hemodynamic monitoring

· Electrocardiogram

· Myocardial enzymogram and biochemical examination

· Histopathology

Transverse aortic constriction (TAC) model

Mice, rats

Drug-induced heart failure models

Rats

Rapid pacing-induced heart failure models

Dogs

Myocardial ischemia and myocardial infarction

LAD ligation models

Mice, rats, pigs,   dogs, NHPs

· Ultrasonic cardiogram

· Invasive hemodynamic monitoring

· Electrocardiogram

· Myocardial enzymogram and biochemical examination

· Histopathology

Coronary occlusion models

Pigs, dogs, NHPs

ISO-induced model

Rats

Pulmonary arterial hypertension (PAH)

Monocrotaline (MCT) induced PAH model

Rats

· Right ventricular systolic pressure (RVSP)

· Right ventricular hypertrophy index (RVHI)

· Histopathology

Hypertension

Genetic models

SHR / DSS rats

· Blood Biochemistry and Routine Blood Tests

· Blood pressure monitoring

· Electrocardiogram (ECG)

2-kidney-1-clip   model

rats

Cardiac arrhythmia

Epinephrine-induced arrhythmia model

Rats, rabbits

· Ultrasonic cardiogram

· Electrocardiogram

Ischemic stroke

Intraluminal suture MCAO model (transient or permanent)

Rats

· Behavioral tests

· Infarct volume (TTC staining)

· Grip test

· Novel object recognition test

· Cerebral blood flow

Photothrombosis model

Endovascular coil occlusion of MCA

NHPs, dogs, pigs

· Neurological deficit score

· Infarct volume (MRI)