Cardio-cerebrovascular Diseases

Cardio-Cerebrovascular Diseases

Greentech Bioscience boasts years of experience in pharmacology and pharmacodynamics, especially in the field of cardiovascular and cerebrovascular diseases. We have established a number of validated animal models of cardiovascular diseases and cerebrovascular diseases, ensuring high quality, reproducible data. In addition to our established models, we can also develop novel models according to your requirements.

Our Animal Models of Cardio-Cerebrovascular Diseases


Animal   Models


Clinical   Assessment

Myocardial hypertrophy and heart failure

Models of ischemic heart failure

Rats, pigs, dogs, NHPs

· Ultrasonic cardiogram

· Invasive hemodynamic monitoring

· Electrocardiogram

· Myocardial enzymogram and biochemical examination

· Histopathology

Transverse aortic constriction (TAC) model

Mice, rats

Drug-induced heart failure models


Rapid pacing-induced heart failure models


Myocardial ischemia and myocardial infarction

LAD ligation models

Mice, rats, pigs,   dogs, NHPs

· Ultrasonic cardiogram

· Invasive hemodynamic monitoring

· Electrocardiogram

· Myocardial enzymogram and biochemical examination

· Histopathology

Coronary occlusion models

Pigs, dogs, NHPs

ISO-induced model


Pulmonary arterial hypertension (PAH)

Monocrotaline (MCT) induced PAH model


· Right ventricular systolic pressure (RVSP)

· Right ventricular hypertrophy index (RVHI)

· Histopathology


Genetic models

SHR / DSS rats

· Blood Biochemistry and Routine Blood Tests

· Blood pressure monitoring

· Electrocardiogram (ECG)

2-kidney-1-clip   model


Cardiac arrhythmia

Epinephrine-induced arrhythmia model

Rats, rabbits

· Ultrasonic cardiogram

· Electrocardiogram

Ischemic stroke

Intraluminal suture MCAO model (transient or permanent)


· Behavioral tests

· Infarct volume (TTC staining)

· Grip test

· Novel object recognition test

· Cerebral blood flow

Photothrombosis model

Endovascular coil occlusion of MCA

NHPs, dogs, pigs

· Neurological deficit score

· Infarct volume (MRI)

Equipment & Device

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