Rheumatoid Arthritis

Collagen-induced arthritis model

Rats

(1) Rheumatoid arthritis score

(2) Paw volume, ankle diameter

(3) ELISA: plasma IL-6, IL-17, TNF-alpha, etc.

(4) Joint histopathology

Adjuvant-induced arthritis model

Psoriasis

Imiquimod-induced psoriasis model

Mice

(1) Psoriasis area severity index (PASI)

(2) Histopathology: H&E staining

(3) Immunostaining: MPO, CD3+, etc.

(4) qPCR: IL-17A, IL-17F, IL-23, TNF-α, IFN-γ, IL-6, IL-17, etc.

Multiple Sclerosis (MS)

Experimental autoimmune encephalomyelitis (EAE) model

SJL/J mice

(1) Body weight

(2) Neurological function score

Systemic Sclerosis (SSc)

Bleomycin-induced SSc model

Mice

(1) Histopathology

(2) Immunostaining: TGF-β

(3) Hydroxyproline content

(4) Serum ANA/ENA testing

Oral Mucositis

Radiation-induced   oral mucositis model

Rats, golden hamsters

(1) Survival, food/water intake

(2) Oral mucosal injury score

(3) Histopathology

Idiopathic Pulmonary Fibrosis (IPF)

Bleomycin induced lung fibrosis model

Rats, golden hamsters

(1) Body weight

(2) Inflammatory cell count of BALFs

(3) Measurement of HYP

(4) Histopathology

Silica induced pulmonary fibrosis model

Inflammatory Bowel Disease (IBD)

DSS induced IBD model

Mice, rats

(1) Clinical observations

(2) Disease activity index (DAI) scores

(3) Colon length, organ weight

(4) MPO activity measurement

(5) ELISA: serum TNF-α, IL-6, IL-8, IL-1β

(6) Histopathology

TNBS induced IBD model