In Vitro Drug Screening
Greentech provides molecular and cellular drug screening solutions ensuring reliable, accurate data and reporting. We developed cellular and molecular function laboratories which conduct in vitro research in cell biology, cellular/molecular mechanism, molecular biology, and biochemistry.
Molecular Level Assays and Drug Screening Services
Enzyme activity assay for kinases, metabolic enzymes, epigenetic enzymes
Interaction detection and binding affinity measurement among proteins, receptors/ligands, and ion channels
Compound screening
Analysis platform
| Detection technologies: Fluorescence intensity, including FRET Fluorescence polarization AlphaScreen®/AlphaLISA® Luminescence, including BRET and Kinase Glo Time-resolved fluorescence, including TR-FRET UV/vis absorbance spectra ELISA |
PHERAstar FSX Microplate Reader for HTS |
Kinase panel screening services
| Tyrosine Kinases | Serine/Threonine Kinases | ||||
ABL (ABL1) | EGFR [T790M] | LTK | AKT1 | IRAK4 | PIM1 |
ABL [E255K] | FER | LYNa | AKT2 | JNK2 (MAPK9) | PIM2 |
ABL [G250E] | FES | MUSK | AKT3 | JNK3 (MAPK10) | PKACα (PRKACA) |
ABL [T315I] | FGFR1 | PDGFRα (PDGFRA) | AMPKα1 (PRKAA1) | MAP4K2 | PKCα (PRKCA) |
ABL [Y253F] | FGFR2 | PDGFRβ (PDGFRB) | AUR A (AURKA) | MAP4K4 | PKCβ1 (PRKCB1) |
ALK | FGFR3 | RAF1 | AUR B (AURKB) | MAPKAPK2 | PKCβ2 (PRKCB2) |
ALK [C1156Y] | FGFR4 | RET | AUR C (AURKC) | MAPKAPK3 | PKCγ (PRKCG) |
ARG (ABL2) | FGR | RON (MST1R) | BRAF | MAPKAPK5 | PKCδ (PRKCD) |
AXL | FLT3 | ROS (ROS1) | BRAF[V599E] | MARK1 | PKCε (PRKCE) |
BLK | FYN [isoform a] | SRC | CaMK2α(CAMK2A) | MARK2 | PKCζ (PRKCZ) |
BRK (PTK6) | FYN [isoform b] | SYK | CaMK2β(CAMK2B) | MARK3 | PKCη (PRKCH) |
BTK | HCK | TIE2 (TEK) | CaMK2γ (CAMK2G) | MASK | PKCθ (PRKCQ) |
CDK4/Cyclin | HER2 (ERBB2) | TRKA (NTRK1) | CaMK2δ (CAMK2D) | MINK (MINK1) | PKCι (PRKCI) |
CDK6/Cyclin | HER4 (ERBB4) | TRKA (NTRK1) | CaMK4 | MSK1 (RPS6KA5) | PKD1 (PRKD1) |
CDK9/Cyclin | IGF1R | TYK2 | CDC2 | MSK2 (RPS6KA4) | PKD2 (PRKD2) |
cKIT | INSR | VEGFR1 (FLT1) | CHK1(CHEK1) | MST1 (STK4) | PKD3 (PRKD3) |
cMET | ITK | VEGFR2 (KDR) | CHK2(CHEK2) | MST2 (STK3) | ROCK1 |
CSK | JAK1 | VEGFR3 (FLT4) | CK1δ (CSNK1D) | MYLK2 | ROCK2 |
ECK/EphA2 | JAK2 | YES (YES1) | CK1ε (CSNK1E) | NEK2 | RSK1 (RPS6KA1) |
EGFR (ERBB1) | JAK3 | ZAP70 | DCAMKL2 | p38α (MAPK14) | RSK2 (RPS6KA3) |
EGFR [L858R] | LCK | DYRK1A | p38β (MAPK11) | RSK3 (RPS6KA2) | |
DYRK1B | p38γ (MAPK12) | SGK | |||
Erk1 (MAPK3) | p38δ (MAPK13) | SGK2 | |||
Erk2 (MAPK1) | p70S6K (RPS6KB1) | SGK3 (SGKL) | |||
GSK3α (GSK3A) | PAK4 | TAOK2 | |||
GSK3β (GSK3B) | PDHK1 (PDK1) | ||||
IKKβ (IKBKB) | PGK (PRKG1) | ||||
Figure 1. HTRF® kinase assay measuring the effects of compound on kinase activity.
Cellular Level Assays and Drug Screening Services
Cellular level function detection platform | Action mechanism and signal pathway research |
Sensitive strain screening Cell cycle, proliferation, cytotoxicity, apoptosis assay Cell migration, invasion, and uptake assay Cytokine induction assay | Immunofluorescence (IF) Immunohistochemistry (IHC) ELISA Western Blot qPCR RT-PCR HTRF AlphaScreen AlphaLISA Flow cytometry (FACS) |
Inquiries
Request a quote now, or email us at BD@greentech-bio.com to inquire about our services or obtain a quote for your project.
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